志贺菌属菌群及血清型18年的变化趋势与耐药性

Distribution and antimicrobial resistant tendency of Shigella spp.group and serotype in diarrhea patients during 18 years

目的监测医院1992-2009年与腹泻有关志贺菌属菌群及血清型18年的变化和耐药趋势,为北京地区的流行病学研究、疫苗的制备及临床合理用药提供依据。方法通过便培养,致病菌经生化及血清学进一步鉴定到种、群或血清型,并以纸片扩散法测定了抗菌药物的敏感性。结果 18年分离出志贺菌属6745株,包括志贺菌属的4个群27个血清型,B群最多占72.0%;D群占27.3%,有明显增多的趋势;福氏志贺菌F2a、F1a分别占73.3%、4.0%;不同菌群对抗菌药物的敏感率有差异,B群多药耐药较多。结论志贺菌属菌群及血清型种类多,随时间的变迁变化明显,耐药性不同,应重视监测并指导防治。

OBJECTIVE To monitor the constitutes and resistant tendency of Shigella spp.group and serotype in diarrheal patients in hospital from 1992 to 2009,to offer the date for guiding epidemiologic study,vaccination research and clinical treatment.METHODS The pathogens cultured from feces had been cultured and identified to family,genus and serotype,then the susceptibility of Shigella to antimicrobial agents was tested by disc diffusion method.RESULTS A total of 6777 isolates were identified during 18 years.Shigella spp.B group（71.7%） was the most frequently pathogens,followed by D group（27.2%）.Serotype F2a and F1a（73.3% and 4.0%） respectively.The sensitive rate of differential group to differential antimicrobial agents is unlikeness.S.flexneri showed higher resistant rate to most of antibiotics.CONCLUSION It should attach great importance to monitor the various groups and serotypes of the Shigella spp,whose drug resistance have changed significantly.