麻黄素并吗啡硬膜外注射的术后镇痛效果

EPIDURAL ANALGESIC EFFECT OF EPHEDRINE AND MORPHINE AFTER OPERATION

①目的 探讨麻黄素并吗啡硬膜外注射的术后镇痛效果。②方法 对１２６ 例泌尿外科开放手术后的病人进行间断硬膜外腔注射吗啡（２ｍ ｇ）、麻黄素（２０ｍ ｇ），观察其镇痛效果，并与４０ 例单用吗啡（ ２ｍ ｇ）者进行对照。③结果 吗啡、麻黄素的镇痛作用强而持久，一次用药有效时间为（２８．４±３．５）ｈ，较对照组的（１８．１±２．６）ｈ 明显延长（ｔ＝ １７．１，Ｐ＜ ０．０１）。未见出现血压波动者。④结论 吗啡加麻黄素硬膜外腔注射是安全、长效的术后镇痛方法，特别适用于术后留置导尿或尿流改道的泌尿外科开放手术。

Objective\ To investigate epidural analgesic effect of ephedrine and morphine after operation. Methods\ 2mg morphine and 20mg ephedrine were injected intermittently into epidural space in 126 postoperative patients of urology department, in other 40 cases (control group) only 2mg morphine used. The analgesia effect between the two groups were compared.\ Results\ The analgesic effect of ephedrine and morphine together were intense and long lasting. The average pain free time was (28.4±3.5) hours which was significantly longer than that of control group ( t=17.1,P <0.01). There was no blood pressure fluctuation caused by ephedrine.\ Conclusion\ The epidural analgesic effect of morphine plus ephedrine was a safe, efficient method, especially suitable for postoperative patients with indwelling catheter or urinary diversion.\;