摘要
将丙二酸与N-羟基琥珀酰亚胺(NHS)在二环己基碳二亚胺(DCC)催化下反应得到丙二酸NHS酯。以丙二酸NHS酯为交联剂对胶原膜进行交联改性,考察不同交联剂浓度对胶原膜物理化学性能的影响,通过测试其变性温度、吸水率、酶解率和机械强度等,来表征交联前后膜性能的改变。结果表明:经过丙二酸NHS酯交联改性后的胶原膜热稳定性、形态稳定性增强,抵抗酶解的能力增加,机械强度有所提高。说明丙二酸NHS酯作为一种交联剂,可有效改善胶原膜的物理化学性能。
Propanedioic acid-NHS ester was prepared by modifying propanedioic acid with N-hydroxysuccinimide（NHS） in the presence of dicyclohexylcarbodiimide（DCC）. Propanedioic acid-NHS ester was used as a crosslinking agent for collagen membrane, and the effect of crosslinking agent dosage on the physicochemical properties of collagen membrane was investigated. The physicochemical properties of the collagen membrane, such as denaturation temperature, water absorption, pancreatin resistance and mechanical strength were tested before and after crosslinking. The results demonstrate that after crosslinking, the thermal stability, morphological stability, enzymatic resistance and mechanical strength of collagen membrane are all improved. It is suggested that propanedioic acid-NHS ester could improve the physicochemical properties of collagen membrane as a crosslinking agent.
出处
《中国皮革》
CAS
北大核心
2011年第15期32-34,39,共3页
China Leather
基金
国家自然科学基金资助项目(20876098)
