不育症男性精浆抗精子抗体与支原体感染的相关性分析

Correlation analysis of antisperm antibody with Mycoplasma infection in male infertility

目的:了解男性不育症患者精浆抗精子抗体(AsAb)与解脲支原体(UU)感染的关系。方法:精浆抗精子抗体采用金标免疫斑点法,解脲支原体采用培养法,分别检测306例男性不育症患者精浆中的抗精子抗体和解脲支原体。结果:306例男性不育症患者中,UU阳性有168例,UU阴性有138例;UU阳性组中精浆AsAb阳性49例,阳性率为29.2%;UU阴性组中,精浆AsAb阳性14例,阳性率为10.1%。精浆AsAb阳性率UU阳性组高于UU阴性组,差异有统计学意义(P<0.05)。结论:解脲支原体感染是男性生殖道感染的常见病原体,UU感染能刺激机体产生AsAb,导致男性免疫性不育。

Objective To understand the correlation of seminal plasma antisperm antibody（AsAb） with ureaplasma urealyticum（UU） infection in male infertility.Method Anti-sperm antibody in seminal plasma was detected with gold-labeled immunospot assay,UU with culture method,and 306 cases of male infertility were detected of anti-sperm antibody in seminal plasma and ureaplasma urealyticum.Results Among 306 cases of male infertility patients,UU positive in 168 cases,UU negative in 138 cases;in UU positive group,49 cases of seminal AsAb positive,the positive rate was 29.2%;in UU negative group,the seminal plasma AsAb positive in 14 cases,the positive rate of 10.1%.The positive rate of UU in seminal AsAb positive group was higher than that in UU negative group,the difference was statistically significant（P0.05）.Conclusion Ureaplasma urealyticum infection is a common male reproductive tract infections caused by pathogens,UU infection can stimulate the body to produce AsAb,leading to male immune infertility.