强烈化疗方案在儿童B-细胞淋巴瘤中的治疗应用(附26例病例分析)

The application of intensive chemotherapy regimens in the treatment of children's B cell non Hodgkin's lymphoma:26 cases analysis

目的 :分析强烈化疗方案对儿童B细胞淋巴瘤的治疗效果。方法 :对 1990年以来按照CHOP/HDMTX和BFM方案治疗的 2 6例儿童B细胞淋巴瘤的疗效进行分析。结果 :2 6例病人完全缓解率 88.5 % ,总有效率 92 .4%。CHOP/HDMTX方案 3年生存率 3 9.5 % ,BFM方案 1年生存率 6 8.6 % ,中位生存时间分别为 2 2 .1和 2 8.1个月。结论 :强烈化疗方案能产生较高的缓解率 ,生存率较过去有所提高。从完全缓解率和生存结果来看 。

Objective:Evaluation the results of intensive chemotherapy regimens in the treatment of children B cell non Hodgkins lymphomas. Methods:Evaluating the results and survival rates of 26 cases childrens B cell non Hodgkins lymphoma treated with CHOP/HDMTX and BFM regimens since 1990. Results:The CR rate was 88.5%for all patients,and overall response rate was 92.4%. The 3 year survival rate (SR) in CHOP/HDMTX regimen was 39.5%and 1 year SR in BFM regimen was 68.6%,The median survival time were 22.1 and 28.1 months respectively. Conclusions:The intensive chemotherapy regimen can produce high CR rate and improved SR . According to the results of CR and SR,we think it is worth to use BFM regimen in more patients and observe its effects in childrenB cell non Hodgkins lymphoma.