钙剂加阿司匹林综合治疗妊娠期高血压疾病的疗效及机制分析

Comprehensive treatment of calcium plus aspirin pregnancy induced hypertension Analysis of therapeutic effects and mechanisms

目的:探讨钙剂联合阿司匹林治疗妊娠期高血压疾病的临床疗效及机制。方法:选取临床有妊娠期高血压疾病的孕妇188例,随机分为对照组和观察组,对照组患者采用常规的解痉、降压、镇静、扩容等药物进行治疗,观察组患者在对照组患者治疗的基础上予以钙剂联合阿司匹林进行综合治疗。比较两组患者治疗前后的动脉血压和尿蛋白测定结果,分析钙剂加阿司匹林综合治疗妊娠期高血压疾病的作用机制。结果:检测两组患者治疗前后的动脉血压和尿蛋白(24 h)检测结果,观察组患者较对照组患者两项指标改善情况更为优异,差异有统计学意义(P<0.05)。结论:于解痉、镇静、降压治疗基础上加用阿司匹林联合钙剂综合治疗妊娠期高血压疾病患者,可以有效遏制疾病的发展,其机制主要是运用了阿司匹林可以抑制血小板的聚集和血栓烷的生产,钙剂可以使血管对血管紧张素敏感性降低,两者联合从根源上解除了孕妇血压升高的因素。

Objective To investigate the calcium in combination with aspirin treatment of pregnancy induced hypertension clinical efficacy and mechanism.Methods Clinical pregnant women with pregnancy hypertension 188 cases were randomly divided into control group and observation group and the control group were treated with conventional antispasmodic,antihypertensive,sedative,expansion and other drugs for treatment,observation group were patients in the control group be based on the comprehensive treatment of calcium in combination with aspirin were compared before and after treatment of blood pressure and urine protein measurement results,the combined treatment of calcium and the mechanism of aspirin.Results The patients were detected before and after blood and urine tests,the result of the observatiaon group was improved better than the control group（P0.05）.Conclusion Aspirin and calcium in combination with other antispasmodic,antihypertensive,sedatives,can effectively curb the development of pregnancy hypertension,the mechanism is the use of aspirin can inhibit platelet aggregation and thromboxane production,Calcium can make blood vessels less sensitive to angiotensin,the two combined to lift from the roots of factors of pregnant women blood pressure.