奥曲肽对小鼠结肠癌肝转移化疗的影响

Influence of 5-fluorouracilum combined with octreotide on chemotherapy of hepatic metastases of colonic carcinoma

目的：探讨生长抑素衍生物奥曲肽（又名善得定）对动物结肠癌肝转移瘤５－氟尿嘧啶（５－Ｆｕ）化学治疗的影响。方法：采用流式细胞术等方法观察奥曲肽对小鼠ＣＴ２６结肠癌肝转移瘤５－Ｆｕ 化学治疗的影响。结果：与对照组比较，奥曲肽加５－Ｆｕ联合治疗后，肿瘤细胞动力学参数（细胞增殖指数和Ｓ期分数）的变化比两者单一用药更为显著，肝脏表面肿瘤数目也更为减少，而小鼠的生存期却相对延长。结论：奥曲肽对５－Ｆｕ 的抗肿瘤作用有一定的增强效应，初步推测这种增强作用的机制与两种制剂对肿瘤细胞周期特异性抑制有关。

Objective: To study the chemotherapy effect of 5 fluorouracilum (5 Fu) combined with octreotide on hepatic metastases of colonic carcinoma. Methods: The influence of chemotherapy by 5 Fu combined with somatostatin analogue octreotide on cytokinetics of hepatic metastases from colonic adenocarcinoma were investigated by flow cytometry. Results: The changes of tumor cytokinetics parameters (e.g. proliferative index, S phase fraction and so on), the incidence of hepatic metastases and the survival time of mice in combined treatment were more obvious than that of single treatment. Conclusion: Octreotide is beneficial to chemotherapy of 5 Fu. The mechanism of anti tumor effect by combination of both may be associated with the inhibitory effect of tumor cell cycle specifically.