转移因子对社区儿童咳嗽变异性哮喘的疗效观察

Clinical observation of transfer factor on children's cough variant asthma of community

目的:观察转移因子对治疗与预防儿童咳嗽变异性哮喘(CVA)的效果,为临床预防CVA提供依据。方法:对160例咳嗽变异性哮喘的患儿,随机分成转移因子组120例和对照组40例,其中转移因子组分1月组40例,2月组40例,3月组40例。二组均在发病时采用相同的治疗方法直到症状消失,转移因子组在治疗方法基础上加用转移因子胶囊口服,疗程结束1个月、2个月、3个月随访。结果:转移因子组与对照组咳嗽消失所需的时间差异无统计学意义(P>0.05),转移因子组中1月、2月、3月组三月随访总复发数分别为25、22、11例,对照组复发数分别为37例,差异均有统计学意义,其中转移因子疗程为3个月的患儿3个月随访总复发率为32.4%,与疗程为1月、2月的患儿3个月随访总复发率比较有统计学意义(P_1=0.002,P_2=0.011)。结论:转移因子预防咳嗽变异性哮喘复发的疗效肯定,其中以连续服用三个月的效果最佳,且副作用小,值得临床推广。

Objective：Observe clinical efficacy about transfer factors on children cough variant asthma,provide basis to guide clinical medication better.Methods：160 cases cough variant asthma were randomly divided into transfer factor and control group,which had 120 cases and 40 cases, including transfer factor components January group 40 cases,February group 40 cases,march group 40 cases.Two groups of all use the same treatment until symptoms disappear,transfer factor in treatment group added with transfer factor capsule,follow-up after 1 month,2 months, 3 months treatment ended.Results：.The differences of the time needed in cough disappeared was not statistically significant（P0.05） in transfer factor and control group.January transfer factor in the group,February and march group total number of march follow-up recurrence were respectively 25,22,11 cases and control recurrence number was 37 cases,respectively were statistically significant differences,transfer factor treatment for 3 months of children 3 months follow-up total recurrence rate was 32.4%,compare with the treatment for January and February,the follow-up recurrence were statistically significant（P1=0.002,P2 = 0.011）.Conclusions：It was assured that transfer factor could prevent recurrence of cough variant asthma,take three months was the best,the side effects and price were small and cheap,worth clinical promotion.