国内布地奈德比较地塞米松吸入治疗小儿急性喉炎的Meta分析

A Meta-Analysis of Budesonide versus Dexamethasone for the Treatment of Acute Laryngitis in Children of China

目的分析国内布地奈德、地塞米松吸入治疗小儿急性喉炎的疗效。方法系统检索中国生物医学文献数字库(CBM)、中国期刊全文数据库(CNKI)、维普、万方数据库,检索时间为各个数据库建库至2010年7月。纳入布地奈德对比地塞米松吸入治疗小儿急性喉炎的随机对照试验(randomized controlled trial,RCT),对纳入研究进行质量评价和Meta分析。结果共纳入11个RCT,分析结果提示两组声嘶、犬吠样咳嗽、呼吸困难、喉喘鸣症状消失时间差异均存在统计学意义,其MD及95%CI分为:-0.88(-1.10,-0.65),-1.43(-2.01,-0.84),-0.48(-0.63,-0.32),-0.59(-0.78,-0.41)。结论基于当前国内证据,布地奈德改善小儿急性喉炎梗阻症状疗效优于地塞米松吸入治疗。

Objective To evaluate the effectiveness of budesonide versus dexamethasone for the treatment of acute laryngitis in children of china.Methods Literatures in CBM,CNKI,VIP,WanFang databases were searched from the time of establishment of these databases till July 2010.Randomized controlled trials（RCT） of budesonide versus dexamethasone for the treatment of acute laryngitis in children were gathered,and quality was evaluated and meta-analysis was carried out.Results Eleven RCTs were identified,and meta-analysis indicated that there were significant differences between the two groups in the disappearing time of hoarseness,barking cough,dyspnea and laryngeal stridor.The MD values and their 95% CI were respectively-0.88（-1.10,-0.65）,-1.43（-2.01,-0.84）,-0.48（-0.63,-0.32）,and-0.59（-0.78,-0.41）.Conclusion Based on current evidence in China,budesonide is better than dexamethasone for the improvement of acute laryngitis in children.