热休克蛋白家族与肿瘤的相关性及其临床应用的研究进展

Research Advancement and Clinical Application on the Relationship between Heat Shock Proteins Family and Tumor

热休克蛋白是一组应激蛋白,在多数肿瘤细胞中表达增高,并参与肿瘤的生长、侵袭、转移等,与患者预后密切相关。本文就HSPs的特点、功能、与肿瘤发生发展的关系及临床应用分别进行介绍,深入了解和认识热休克蛋白与肿瘤之间发生作用的机制和规律,对研究肿瘤的防治策略具有重要意义。

Heat shock proteins （HSPs） family is a set of stress proteins, which express at high levels in various kinds of tumor ceils and is involved in tumor growth, invasion and metastasis. It is closely related to the prognosis of cancer patients. This article mainly reviews the characteristics and functions of HSPs, the relation- ship between HSPs and tumor genesis, its development and the clinical application. In-depth familiarity with the mechanism and pattern of interaction between HSPs and tumor play an important role in the study of tumor＇ s prophylaxis policy.