金黄色葡萄球菌肠毒素B在变态反应性疾病发病机制中的作用

Effects of staphylococcal enterotoxin B in the pathogenesis of allergic disease

变态反应性疾病的发病率逐年上升,Ⅰ型超敏反应是其主要的发病机制。近年来研究发现,金黄色葡萄球菌肠毒素B不但可以作为变应原诱导变态反应性疾病的发生,而且还可以作为超抗原影响免疫调节细胞和促炎细胞活性,在变态反应性疾病中发挥极其重要的作用。本文对金黄色葡萄球菌肠毒素B在变应性鼻炎、哮喘及特应性皮炎几种常见变态反应性疾病发生、发展中的作用机制作一综述。

The prevalence of allergic disease increased over the last few decades.Type I hypersensitivity is the main pathogenesis of allergic disease.Staphylococcal enterotoxin B could act as allergen to induce allergic disease.In addition,staphylococcal enterotoxin B could act as superantigen to regulate the activity of immuno-modulatory and pro-inflammatory cell types,and play an important role on allergic disease.Here,we summarize the effects of staphylococcal enterotoxin B in the pathogenesis of allergic disease such as allergic rhinitis,asthma and atopic dermatitis.