壳聚糖─海藻酸钠微囊对蛋白质控制释放的研究

Protein Controlled Release from Chitosan Sodium Alginate Microcapsules

采用乳化法制备了可注射用壳聚糖海藻酸钠微囊， 其粒径小于２００ μｍ ，且具有相对较窄的近似高斯分布。牛血清白蛋白作为模型药物在微囊中的包埋率可超过５０ ％ 。通过壳聚糖在海藻酸钠微囊表面的复合，牛血清白蛋白从微囊中的持续释放时间从几个小时延长到半个月以上。

The chitosan sodium alginate microcapsules for injectable usage were prepared by emulsification method. The diameter of microcapsules is less than 200 micron and posses a relative narrow and normal gauss distribution. The loading efficiency of Bovine Serum Album(BSA) in microcapsules is more than 50%. By the coating with chitosan on the surface of sodium alginate microcapsules, the BSA release from microcapsules is extended from several hours to more than half a month.