脑梗死伴牙周炎患者CRP、IL-6和sICAM-1水平检测的研究

Clinical significance of C-reactive protein,interleukin-6 and soluble intercellular adhesion molecule 1 in patients with cerebral infarction and periodontal disease

目的:探讨慢性牙周炎与脑梗死患者血清中C-反应蛋白(CRP)、白细胞介素6(IL-6)和可溶性细胞间黏附分子1(sICAM-1)水平变化及相关关系。方法:纳入经头颅CT或MRI证实确诊脑梗死并伴牙周炎的患者[(CI+CP)组]33例,单纯慢性牙周炎患者(CP组)30例,脑梗死患者(CI组)32例和健康志愿者(H组)38例。记录简化牙石指数、探诊岀血阳性率、探诊深度和附着水平丧失,检测血清中CRP、IL-6和sICAM-1的含量。结果:各组间牙周病指数差异有显著性(P<0.05),与CP组、CI组、H组相比,(CI+CP)组的CRP、IL-6和sICAM-1水平明显升高(P<0.01)。结论:CRP、IL-6和sICAM-1可能与脑梗死和牙周炎病理机制相关,牙周炎和脑梗死之间存在一定的关联。

Objective： To explore the possible relationship of serum levels of C-reactive protein（CRP）,interleukin-6（IL-6） and soluble intercellular adhesion molecule 1（sICAM-1） of patients with chronic periodontitis（CP） and cerebral infarction（CI）.Methods： 133 subjects were included in this study.Among them,33 were patients with CI and CP（group CI＋CP）,30 with CP（group CP）,32 with CI（group CI） and 38 were healthy volunteers（group H）.The periodontal indexes and the serum levels of CRP,IL-6 and sICAM-1 were measured.Results： The periodontal indexes including calculus index,bleeding on probing,probing depth and attachment loss were significantly different among the four groups.In groups of CI＋CP,CP and CI the CRP,IL-6 and sICAM-1 levels were significantly higher than those in the group H（P0.01）.Conclusion： CRP,IL-6 and sICAM-1 might be closely related with the pathogenesis of CI and CP.A certain correlation might exist between CI and CP.