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肌肉特异性microRNA功能及运动对其影响的研究进展 被引量:3

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摘要 长时间有规律的训练能增加骨骼肌大小及其力量,改善骨骼肌对抗疲劳、提高骨骼肌利用碳水化合物和脂肪氧化供能的能力。而年龄增长、久坐不动的生活方式和一些慢性疾病会引起骨骼肌体积和功能衰减,如肌肉衰减征(sarcopenia)。目前对于运动调节骨骼肌适应的分子生物学机制并不是很清楚,最近关于肌肉特异性microRNA的研究为我们了解骨骼肌的适应提供了一个新的视野。
出处 《中国运动医学杂志》 CAS CSCD 北大核心 2011年第7期685-690,共6页 Chinese Journal of Sports Medicine
基金 教育部博士点基金项目(200802690017)
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参考文献46

  • 1Hamilton MT, Booth FW .Skeletal muscle adaptation to exercise :a century of progress. J A0pl Physiol, 2000, 88 (1) : 327-331.
  • 2Greenlund LJS, Nair KS. Sarcopenia-consequences, mechanisms, and potential therapies. Mech. Ageing Dev, 2003, 124 (3) :287-299.
  • 3Bartel DE MicroRNAs : genomics, biogenesis, mecha- nism, and function. Cell, 2004, 116 (2):281-297.
  • 4Lee Y, Ahn C, Han J, et al. The nuclear RNase III Drosha initiates microRNA processing. Nature, 2003, 425 (6965) : 415-419.
  • 5Wienholds E, Plasterk RH. MicroRNA function in ani- mal development. FEBS Lett, 2005, 579 (26) : 5911- 5922.
  • 6Xie X, Lu J, Kulbokas EJ, et al. Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature, 2005, 434 (7031) :338-345.
  • 7Cannell IG, Kong YW, Bushell M. How do microR- NAs regulate gene expression? Biochem Soc Trans, 2008, 36 (6): 1224-1231.
  • 8McCarthy JJ, Esser KA. MicroRNA-1 and microRNA- 133a expression are decreased during skeletal muscle hypertrophy. JAppl Physiol, 2007, 102 ( 1 ) : 306-313.
  • 9McCarthy JJ, Esser KA, Andrade FH. MicroRNA-206 is overexpressed in the diaphragm but not the hind limb muscle ofmdx mouse. Am J Physiol Cell Physiol, 2007, 293 (1) : C451-C457.
  • 10Small EM, O' Rourke JR, Moresi V, et al. Regula- tion of PI3-kinase/Akt signaling by muscle-enriched microRNA-486. PNAS, 2010, 107 (9) : 4218-4223.

二级参考文献44

  • 1张宏,徐俊,严隽陶,吴信忠,程杰峰,严振.推拿对骨骼肌减少症患者伸膝速度和肌电的干预作用[J].上海中医药大学学报,2005,19(2):40-41. 被引量:31
  • 2FANòG,MECOCCI P,VECCHIET J,et al.Age and sex influence on oxidative damage and functional status in human skeletal muscle[J].J Muscle Res Cell Motil,2001,(22):345-351.
  • 3KENT-BRAUN J A.Skeletal muscle oxidative capacity in young and older women and men[J].J Appl Physiol,2000,(89):1072-1078.
  • 4RASMUSSEN U F,KRUSTRUP P,KJAER M,et al.Human skeletal muscle mitochondrial metabolism in youth and senescence:no signs of functional changes in ATP formation and mitochondrial oxidative capacity[J].Plungers Arch,2003,(446):270-278.
  • 5SIU P M,PISTILLI E E,BUTLER D C,et al.Aging influences the cellular and molecular responses of apoptosis to skeletal muscle unloading[J].Am J Physiol Cell Physiol,2005,(288):C338-C349.
  • 6DUPONT-VERSTEEGDEN E E.Apoptosis in muscle atrophy:Relevance to Sarcopenia[J].Exp Gerontol,2005,(40):473-481.
  • 7WARNER H R.Apoptosis:a two-edged sword in aging[J].Ann NY Acad Sci,1999,(887):1-11.
  • 8DIRKS A M,HOFER T,MARZETTI E,et al.Mitochondrial DNA mutations,energy metabolism and apoptosis in aging muscle[J].Aging Res Rev,2006,(5):179-195.
  • 9DIRKS A,LEEUWENBURGH C.Apoptosis in skeletal muscle with aging[J].Am J Physiol Regul Integr Comp Physiol,2002,(282):R519-R527.
  • 10PHILLIPS T,LEEUWENBURGH C.Muscle fiber-specific apoptosis and TNF-alpha signaling in Sarcopenia are attenuated by life-long calorie restriction[J].FASEB J,2005,(19):668-670.

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