摘要
背景1-磷酸鞘氨醇（sphingosine-1-phosphate，s1P）是鞘脂的代谢产物，不仅与细胞表面特定受体（S1PR1-5）结合产生多种生物学效应，还作为细胞内第二信使发挥作用。S1P在细胞增殖、移动、凋亡及心血管系统、免疫系统等方面都有重要的调节作用，因而参与到生物体内许多生理和病理过程。目的现就近年来的研究进展，对S1P在肺缺血／再灌注损伤（pulmonaryischemia／reperfusioninjury，PI/RI）中的作用进行综述。内容S1P通过调控炎症反应、减少细胞凋亡以及维持血管内皮屏障完整，与PURl的发生发展存在密切关系。趋向随着对SIP研究的深入，将为PI／RI的防治提供更好的策略。
Background Sphingosine-1-phosphate （S1P） is a sphingolipid metabolite. S IP can not only regulate various biological effects by binding the specific receptor （SIP G protein-coupled receptors, S1PR1-5） on cell surface, but also act as an intracellular second messenger. S1P has a pivotal role in cell proliferation, migration, apoptosis and cardiovascular system and immune system. Thus, it involves in some physiological and pathological progress. Objective This article intends to provide a review about the function of S1P in pulmonary isehemia/reperfusion injury （PURl）, based on published data recently. Content Recent studies suggest that, through regulating inflammation, anti-apoptosis and maintaining endothelial cell barrier, SIP can affect the occurrence and development of PIRI. Trend With the further research on S1P, it offers several novel therapeutic strategies for the treatment of PI/RI.
出处
《国际麻醉学与复苏杂志》
CAS
2011年第4期485-489,共5页
International Journal of Anesthesiology and Resuscitation
关键词
1-磷酸鞘氨醇
肺
缺血
再灌注
Sphingosine-l-phosphate
Lung
Ischemia/reperfusion
