摘要
背景随着心肌缺血／冉灌注损伤（ischemia／reperfusion injury，I／RI）机制及心肌保护机制研究的深入，药物后处理作为一种更具有临床实用价值的心肌保护方法成为了研究热点。目的阐述药物后处理用于心肌保护时，相关药物所模拟内源性保护机制的主要环节以及近年来药物后处理的研究概况和前瞻。内容介绍药物后处理用于心肌保护时，主要途径、作用靶点以及相关药物。趋势药物后处理心肌保护机制的研究和深入将会发现更多的药物靶点，独特的操作便利性，必将更好的应用于临床服务于患者。
Background With the further study on the mechanisms of myocardial ischemia/reperfusion injury and cardioprotection, pharmacolgical posteonditioning becomes the research hotspot because of its clinical application value. Objective To illustrate the endogenous protective emechanisms mimicked by pharmacolgical postconditioning, and the situation as well as prospect of protective effects of pharmacological posteonditioning in myocardial ischemia/reperfusion injury. Content To introduce the main means,targets and related drugs of pharmaeolgical postconditioning. Trend The deeper researches will be done, the more drug targets will be found. Pharmacolgieal postconditioningwill better applied to clinical service in patients because of its unique ooerative eonvenience.
出处
《国际麻醉学与复苏杂志》
CAS
2011年第4期490-493,509,共5页
International Journal of Anesthesiology and Resuscitation
关键词
药物后处理
心肌保护
机制
Pharmacolgical postconditioning
Cardioprotection
Mechanism
