阻塞性睡眠呼吸暂停低通气综合征患者载脂蛋白A-Ⅳ水平的研究

Research on apo A-Ⅳ of obstructive sleep apnea-hypopnea syndrome

目的研究阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea—hypopnea syndrome，OSAHS）患者载脂蛋白A-Ⅳ（ApoA-Ⅳ）水平，以及与血脂水平的相关性。方法63例在上海交通大学医学院附属瑞金医院睡眠中心行多导睡眠图监测的患者，根据睡眠呼吸暂停低通气指数（AHI）分为对照组（AHI〈5次／h）9例，轻度组0SAHS14例（5次／h≤AHI〈15次／h）、中度组OSAHS11例（15次／h≤AHI〈30次／h）及重度组OSAHs29例（AHI≥30次／h）。测定血脂及血ApoA-Ⅳ水平，比较不同严重度OsAHS患者ApoA-Ⅳ水平及其与血脂及AHI的相关性。结果对照组ApoA-Ⅳ明显高于重度0sAHS组，TC、LDL、ApoB水平随AHI的升高而增加，（r分别为0．303，0．303、0．258，P〈0．05）；ApoA-Ⅳ与TG呈正相关（r=0．51，P〈0．001）。结论ApoA-Ⅳ水平与OSAHS患者严重程度相关，初步提示ApoA-Ⅳ在OSAHS心血管损伤中起一定作用。

Objective To investigate the serum level of Apo A-Ⅳ （apolipoprotein A-Ⅳ ） of OSAHS patients, and the correlation with serum lipid. Methods Subjects were divided into four groups based on various AHI, i.e. control, mild, moderate and severe groups （9,14,11,29 eases, respectively）. The difference of Apo A-Ⅳ level among groups and the relationship between Apo A-Ⅳ and AHI were studied. Results The level of Apo A-Ⅳ was lower in the severe patients than control, TC, LDL, ApoB was positively correlated with AHI （ r ： 0. 303,0. 303,0. 258, respectively, P d0.05） ; Apo A-Ⅳ was positively correlated with TG（ r =0.51, P d0. 001）. Conclusions Apo A-Ⅳ was correlated with severity of OSAHS, and it suggested Apo A-Ⅳ be involved in cardiovascular injury.