坎地沙坦酯联合吲达帕胺治疗老年原发性高血压的疗效观察

Efficacy Observation of Candesartan Ester Combined with Indapamide in the Treatment of Elderly Primary Hypertension

目的:观察坎地沙坦酯联合吲达帕胺治疗老年原发性高血压的疗效和安全性。方法:将我院原发性高血压患者85例随机分为2组,联合用药组43例,给予坎地沙坦酯(4mg·d-1,qd)+吲达帕胺(2.5mg·d-1,qd);单药组42例,单用坎地沙坦酯(4mg·d-1,qd)降压。2组均治疗4周。比较2组治疗前后的降压幅度、疗效、不良反应。结果:用药4周后,联合用药组显效29例,有效9例,总有效率88.4%;单药组显效21例,有效8例,总有效率为69.0%。2组总有效率及降压幅度比较差异有统计学意义(P<0.05)。2组均未见严重不良反应。结论:坎地沙坦酯联合吲达帕胺治疗老年原发性高血压较单独用药效果好,且不良反应少。

OBJECTIVE：To observe the therapeutic efficacy and safety of candesartan ester combined with indapamide in the treatment of elderly primary hypertension. METHODS： 85 cases of elderly primary hypertension were randomly divided into 2 groups： 43 cases in combined treatment group received small dose candesartan ester （4 mg·d-1,qd）and indapamide（2.5 mg·d-1,qd）; 42 cases in single-agent group received candesartan ester （4 mg·d-1,qd） alone to decreasing blood pressure. The blood pressure lowering range and curative effect change were compared between 2 groups before and after treatment. RESULTS： After 4 weeks, as for combined treatment group, 29 cases were significantly effective and 9 cases were effectual with the total effective rate of 88.4%; as for single-agent group, 21 cases were significantly effective and 8 cases were effectual with the total effective rate of 69.0%. Total effective rate of 2 groups had statistical significance（P0.05）. There were no serious ADR in 2 groups. CONCLUSION： Candesartan ester combined with indapamide is better than candesartan ester alone in the treatment of elderly primary hypertension.