阿昔洛韦与泛昔洛韦治疗带状疱疹的疗效观察

Efficacy Observation of Acyclovir and Famciclovir in the Treatment of Herpes Zoster

目的:观察阿昔洛韦与泛昔洛韦治疗带状疱疹的疗效。方法:将我院收治的302例带状疱疹患者随机分为A、B组,其中A组(阿昔洛韦组)150例,B组(泛昔洛韦组)152例。详细记录2组患者的止疱时间、结痂时间、止痛时间、痊愈时间等。结果:治疗随访1周时,A组痊愈率为37.8%,B组痊愈率为52.5%,2组比较差异有统计学意义(P<0.05)。治疗随访第2周和第3周时,2组的有效率、痊愈率和总有效率比较差异均无统计学意义(P>0.05)。B组后遗神经痛的发生率(6.0%)显著低于A组(14.3%),2组比较差异有统计学意义(P<0.05)。结论:泛昔洛韦治疗带状疱疹比阿昔洛韦起效快,可有效缩短病程。

OBJECTIVE：To observe therapeutic efficacy of acyclovir and famciclovir in the treatment of herpes zoster. METHODS： 302 cases of herpes zoster admitted in our hospital were randomly divided into group A and B. 150 cases in group A were given acyclovir, and 152 cases in group B were given famciclovir. Times of response, scab form, analgesia, recovery in 2 groups were recorded in detail. RESULTS： After 1 week following-up, the cure rate of group A was 37.8% and that of group B was 52.5%, there was statistical significance （P0.05）. After 2 and 3 weeks following-up, the effective rate, cure rate and total effective rate in 2 groups had no statistical significance （P0.05）. The incidence of postherpetic neuralgia of group B（6.0%） was lower than group A（14.3%）, there was statistical significance （P0.05）.CONCLUSION： Famciclovir compared with acyclovir in the treatment of herpes zoster has a rapid onset.