夜间动态血压负荷值增高对高血压病的预测意义

Predictive Value of Nighttime Ambulatory Blood Pressure Load for Hypertension

目的探讨24h动态血压平均水平在正常范围,夜间血压负荷值增高的患者3年后发生高血压的情况。方法前瞻性连续收集2005—2007年经24h动态血压检查、昼夜平均血压均在正常范围内,但收缩压(SBP)和(或)舒张压(DBP)夜间负荷值增高的患者(研究组,n=97),并与同期行24h动态血压检查、血压昼夜的平均水平和负荷值均在正常范围内的患者(对照组,n=206)进行比较,观察3年后两组的血压变化情况。结果研究组与对照组3年后发生高血压的比例分别为25.8%和8.7%,差异有统计学意义(P<0.001)。结论夜间动态血压负荷值增高是未来进展至高血压的重要危险因素。

Objective To investigate the incidence of hypertension after 3 years follow-up in patients with the normal levels of 24 h ambulatory blood pressure but increased with nighttime blood pressure load value. Methods With 24 h ambulatory blood pressure monitoring, the patients with the normal levels of 24 h blood pressure but nighttime systolic and diastolic blood pressure load value increased were collected from 2005 to 2007 and compared with patients who had normal levels of 24 h blood pressure and normal nighttime blood pressure load value. Changes in these 3 years between two groups were studied. Results The incidence rate of hypertension was higher in research group than in control group （25.8% vs. 8.7%, P〈0.001）. Conclusion The increase of nighttime blood pressure load value was the risk factors for predicting progression to hypertension in the future.