9752例泌尿生殖系支原体感染及药敏试验分析

Genitourinary mycoplasma infection in 9752 cases and their drug susceptibility test

目的了解本地区泌尿生殖系支原体感染状况和药物敏感试验情况,为临床合理用药提供依据。方法对2006年1月-2010年12月9 752例患者临床症状及支原体培养鉴定及药物敏感试验进行统计学分析。结果 9752例泌尿生殖系感染患者支原体阳性6 215例,阳性率占63.7%,本地区以解脲支原体检出为主,且5年间感染人群呈上升趋势:35.1%、38.2%、47.6%、48.9%、49.7%,女性多于男性。其中解脲支原体(Uu)、人型支原体(Mh)同时阳性的患者除了强力霉素、美满霉素、交沙霉素敏感率高外,其余耐药性达56%以上。结论 Uu、Mh感染后容易引起泌尿生殖器炎症,临床医生应及时取分泌物做支原体培养和药物敏感试验,合理运用抗菌素。

Objective To investigate the genitourinary mycoplasma infection and drug susceptibility test in our region in order to provide the evidence for rational use of drugs.Methods Clinical symptoms of 9 752 patients with genitourinary mycoplasma infection admitted to our hospital from January 2006-December 2010,and their mycoplasma culture identification and drug susceptibility test were statistically analyzed.Results Of the 9 752 patients,6 215（63.7%） were positive for genitourinary mycoplasma.The main pathogen was mycoplasma urealytium（Uu）.The number of Uu-infected patients tended to increase in the past 5 years during which the positive infection rate was 35.1%,38.2%,47.6%,48.9%,and 49.7%,respectively.The positive infection rate was higher in women than in men.The patients infected with both Uu and Mh were sensitive to doxycycline,minocycline and josamycin but resistant to other drugs（over 56%）.Conclusion Uu and Mh infection can induce genitourinary inflammation.It is necessary for clinical physicians to culture mycoplasma,conduct drug susceptibility tests,and rationally use antibiotics.