吡柔比星与阿霉素为主的方案治疗非霍奇金淋巴瘤30例疗效比较

Clinical Observation on the Combination Regimen with Pirarubicin for the Treatment of non- Hodgkin Lymphoma

【目的】分析比较吡柔比星（吡喃阿霉素，THP）与盐酸阿霉素（ADM）治疗非霍奇金淋巴瘤（NHL）的疗效与不良反应。【方法】将58例NHL患者随机分成两组，A组30例，选用THP联合化疗；B组28例，选用ADM联合化疗，4个疗程后比较两组疗效及不良反应。【结果】A组与B组比较，总有效率分别为76．66％和71．43％，A组高于B组，但差异无显著性（P〉0．05）。两组心脏毒性发生率分别为6．25％和17．66％，胃肠道反应分别为50％和67．66％，两者比较有显著性差异（P〈0．05），脱发分别为37．5％和82．14％，两者比较有非常显著性差异（P〈0．01），骨髓抑制两者比较无明显差异。【结论】THP相对于ADM联合化疗患者不良反应发生率低，尤其消化道反应、脱发率及心脏毒性较低，且程度上也较轻，故THP较适合用于NHL患者。

[Objective]To compare the efficacy and adverse effects of pirarubiein（THP） vs adriamycin hydrochloride（ADM） for the treatment of non-Hodgkin lymphoma（NHL）. [Methods]Totally 58 NHL patients were randomly divided into two groups. Group A（ n = 30） was treated with THP combination chemotherapy. Group B （ n =28） was treated with ADM combination chemotherapy. The efficacy and adverse reactions were evaluated and compared after 4 courses of treatment. [Results] The overall response rate of group A was 76.66% which was higher than that of group B（71.43%）, but there was no significant difference between two groups（ P 〉0.05）. The incidence of cardiac toxicity in group A and group B was 6.25% and 17. 66%, respectively, and the incidence of alimentary tract response was 50% and 67. 66%, respectively, and there were significant differences between two groups（ P 〈0.05）. The incidence of alopecia in group A and group B was 37.5% and 82.14%, respectively, and there was very significant difference between two groups（ P 〈0.01）. There was no obvious difference in the incidence of myelosuppression between two groups. [Conclusion] Compared with ADM, THP has lower incidence of side effects, especially alimentary tract reaction, cardiac toxicity and alopeeia, and these adverse reactions are milder. Therefore, THP is more suitable for the treatment of NHL patients, especially for senile NHL patients.