寻常型银屑病患者外周血Th17细胞型因子的检测及意义

Detection of Th17-related Cytokines in Peripheral Blood of Patients With Psoriasis Vulgaris

【目的】探讨Th17细胞相关因子在银屑病患者中的表达及意义。【方法】选择寻常型银屑病患者36例和健康体检人员18例，检测并比较银屑病患者和正常者外周血血清中白细胞介素-17（IL-17）、白细胞介素-23（IL-23）及转化生长因子-β（TGF-β）mRNA表达水平。【结果】银屑病患者血清中IL-17及IL-23水平均显著高于正常对照组（P〈0．01）；银屑病患者外周血PBMC中TGF-βmRNA表达水平显著低于正常对照组（P〈0．01）。【结论】Th12，细胞相关因子在银屑病的免疫发病机理中可能起着重要作用。

[Objective] To explore the expression of Th17-related cytokines in patients with psoriasis and its significance. [Methods]Thirty six cases of psoriasis vulgaris and 18 healthy persons were selected. The expression of IL17, IL-23 and TGF-β mRNA in serum and peripheral blood of patients with psoriasis and normal people were detected and compared. [Results]The levels of IL-17 and IL-23 in serum of patients with psoriasis were significantly higher than those in normal control group（ P 〈0.01）. The level of TGF-β mRNA in peripheral blood mononuclear celI（PBMC） of patients with psoriasis was significantly lower than that in normal con trol group（ P 〈0.01）.