乳腺癌中血管内皮生长因子及半乳糖凝集素-3蛋白表达及其临床意义

The Relationships between the expressions of VEGF and the Galectin-3 and the clinic pathologic parameters in breast carcinoma

目的:探讨乳腺癌中血管内皮生长因子(VEGF)和半乳糖凝集素-3(Galectin-3)表达与临床病理参数的关系。方法:采用免疫组织化学EnVision法检测乳腺癌65例组织中VEGF和Galectin-3的表达。结果:VEGF和Galectin-3在乳腺癌中阳性表达分别44例(67.69%)、53例(81.54%)。乳腺癌中VEGF和Galectin-3的表达均与肿瘤的TNM分期、组织学分级和淋巴结转移有关(P<0.05),乳腺癌中VEGF的表达与Galectin-3表达呈正相关(r值=0.2648,P<0.05)。结论:VEGF和Galectin-3的表达与乳腺癌的浸润转移能力有关,两者在促进肿瘤的浸润转移中发挥协同作用。

Objective：To study the relationship between the expression of VEGF and Galectin-3 and the clinicopathological parameters in breast cancer.Methods：The expressions of VEGF and Galectin-3 were detected by immunohistochemical EnVision technique in 65 cases of breast cancer and were analysed combined with clinical and biological characteristics.Results：The positive rates of VEGF and Galectin-3 in breast cancer were 67.69% and 81.54% respectively the expression of VEGF was related to TNM stage,histological grade and lymph node metastasis（P〈0.05）;The expression of Galectin-3 was correlated with TNM stage,histological grade and lymph node metastasis（P〈0.05）;The expression of VEGF was correlated with Galectin-3（P〈0.05）.Conclusion：The Expressions of VEGF and Galectin-3 may be correlated with invasion and metastasis potency of the breast cancer.They may play a synergistic role in tumor invasion and metastasis.