血清抵抗素与颈动脉粥样硬化和急性脑梗死的关系

Relationship Between Serum Resistin and Carotid Atherosclerosis,Acute Cerebral Infartion

目的探讨血清抵抗素与脑梗死和颈动脉粥样硬化的关系。方法对68例急性脑梗死患者与80例健康体检者行颈动脉彩超检测,观察颈动脉内膜-中膜厚度、颈动脉斑块及斑块评分。用酶联免疫吸附测定法检测血清抵抗素水平。比较脑梗死组和对照组血清抵抗素、颈动脉内膜-中膜厚度、斑块评分的关系。结果脑梗死组血清抵抗素水平较对照组明显升高(23.06±2.47 mg/L比12.63±1.99 mg/L,P<0.0 1);对颈动脉粥样硬化的各主要危险因素行有序分类Logistic回归分析显示,抵抗素、血压控制情况和年龄、低密度脂蛋白胆固醇、高敏C-反应蛋白进入回归方程。结论脑梗死组抵抗素水平较对照组增高;抵抗素是颈动脉粥样硬化的危险因素。

Aim To obeserve the serum resistin expression in cerebral infarction and carotid atherosclerosis. Methods Carotid atherosclerosis of all enrolled objects were evaluated by ultrasonography and the level of resistin were detected in blood plasma by enzyme-linked immunosorbent assay （ELISA）. The resistin content in cerebral infarction group was compared with control group. The relationships between resistin and carotid intima-media thickness （ IMT）, carotid plaque scores were analysed. Results 82.4% patients were detected to have carotid atherosclerosis in cerebral in- farction group, and 36. 3% patients were detected to have carotid atherosclerosis in control group. The level of resistin in cerebral infarction group was higher than in control group （23.06±2.47 mg/L vs 12. 63 ± 1.99 mg/L, P 〈0. 0 1 ）. Re- sistin, blood pressure, age, LDLC, high-sensitive C-reactive protein （hs-CRP） were the major risk factors of carotid atherosclerosis by Logistic. The level of resistin was positively correlated with eartiod IMT, plaque scores, LDLC and hs-CRP in plasma, and the pearson eofficient were 0. 22, 0. 24, 0. 17, 0. 25 （ P 〈 0. 05 ）. Conclusion The resistin level increases in cerebral infarction group, and the resistin may be the risk factor of carotid atherosclerosis.