HIV阳性患者器官移植现状

The current situation of solid organ transplantation in HIV-infected patients

艾滋病(acquired immune deficiency syndrome,AIDS)在世界范围内蔓延,其流行形势在我国亦不容乐观。目前,由于强化抗逆转录病毒治疗(highly active anti-retroviral therapy,HAART)的普及,人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染患者寿命不断延长,主要死因已经演变为主要器官功能的衰竭(如:终末期肝病、肾病)。随着器官移植技术的成熟,越来越多的器官移植中心尝试扩大原来的移植手术适应证以挽救HIV阳性患者的生命。虽然在这方面已经积累了不少经验,但是鉴于这个领域技术操作的复杂性,截至目前,仍存在许多亟待解决的问题。本文针对HIV阳性患者器官移植的关键问题进行综述,旨在增加国内对这个领域发展的了解,并对我国HIV阳性患者的救治工作提供有益思路。

The acquired immune deficiency syndrome（AIDS） has spread throughout the world,and the situation in china is also not optimistic.At present,the life span of human immunodeficiency virus（HIV）-infected patients has been prolonged greatly because of the popularity of highly active anti-retroviral therapy（HAART） therapy,and the important organ function failure such as liver function failure or kidney function failure became the main causes for mortality in those patients.With the dramatic improvements in solid organ transplantation,more and more transplantation centers are attempting to widen original indication of organ transplant for saving more HIV-infected patients who has the major organ function failure.Being complexity of transplant on HIV-infected patients,although many doctors gained the experience from the past transplant cases,there still remains many questions unsolved.The aims of this review are to make the key issues of the HIV-infected transplantation familiar to Chinese doctors and to provide useful information on how to save HIV-infected patients in China.