DAB2IP基因的研究进展

Progress on DAB2IP gene

hDAB2IP（human DOC2/DAB2 interaction protein）基因为一种新发现的肿瘤抑制基因,参与细胞的信号转导,影响细胞的生长发育和凋亡,近来的研究发现它在多种恶性肿瘤的发生发展过程中表达下调,因而引起人们的关注。DAB2IP是Ras GTPase-activating protein（Ras GAP）家族的新成员,它与DAB2/DOC2蛋白的N末端相结合,是DAB2信号途径的下游效应器;而DAB2是一个重要的肿瘤抑制基因,在多种肿瘤的发生中发挥作用。DAB2IP作为一种新的GTPase激活蛋白,

Human DAB2 interaction protein（DAB2IP） is a novel member of Ras GTPase-activating protein family.It interacts directly with disabled-2 protein（DAB2/DOC2） which suppresses growth of cancers derived from different tissues,including mammary,prostate and ovarian cancers.DAB2IP was identified as an immediate downstream effector mediated by DAB2/DOC2.DAB2IP and DAB2/DOC2 form a unique protein complex that has a negative regulatory effect on the Ras-mediated signal pathway.It is demonstrated that DAB2IP is a tumor suppressor gene inactivated by methylation in several cancers.This article reviews the structure and biological functions of DAB2IP gene as well as its potential roles in carcinogenesis and evolution.