激素补充治疗后乳腺的超声分型与病理的对比分析

Comparative analysis of breast ultrasonic classification and pathology after hormone repeal therapy

目的探讨激素补充治疗（HRT）后乳腺的超声分型与病理的相关性。方法选取我院接受HRT的围绝经及绝经期患者75例（研究组），HRT时间为6个月～16年；另取同期就诊有绝经期症状的围绝经及绝经期患者43例（对照组），均未接受HRT治疗。基于受检者乳腺终末导管小叶单元的退化程度，以单侧乳腺为统计单位，二维超声检查分析乳腺的超声分型，粗针活检组织条及手术获取病理结果。并将两组超声分型与病理结果进行对比分析。结果超声分型结果：研究组中腺体型占4．0％（3／75），腺纤维型占84．0％（63／75），脂肪型占12．0％（9／75）；对照组中腺体型占27．9％（12／43），腺纤维型占62．7％（27／43），脂肪型占9．4％（4／43），两组间超声分型比较，差异有统计学意义（P〈0．05）。病理结果：研究组腺体增生24例，腺体萎缩51例；对照组中腺体增生19例，腺体萎缩24例，两组间比较差异无统计学意义（P〉0．05）。结论定期超声检查监测HRT患者乳腺结构及分型的变化，对HRT的安全性可起到指导作用。

Objective To investigate the correlation between breast ultrasonic classification and pathology after hormone repeal therapy（HRT）. Methods HRT group included 75 perimenopausai and postmenopausni women with 6 month 16 years HRT （ study group）, and control group included 43 patients without HRT. Based on the regression degree of terminal duct lobular unit, two -dimensional ultrasound was performed to classify the breast by using unilateral breast as statistics unit. Then core needle biopsy with ultrasound guidance was performed and the tissues were examined by pathology. The ultrasound results were compared with those of pathology. Results In HRT group, the glandular type accounted 4.0% （ 3/75 ） , fibroglandular type accounted 84.0% （ 63/75 ） and fatty type accounted 12.0% （ 9/75 ）. While in non - HRT group, the glandular type accounted 27.9% （ 12/43 ）, fibroglandular accounted 62.7% （ 27/43 ）, fatty type accounted 9.4% （4/43） in ultrasonic classification. There was significant difference between two groups （ P 〈 0.05 ）. The pathological results showed 24 cases of gland hyperplasia and 51 cases of gland atrophy in HRT group ,while 19 cases of gland hyperplasia and 24 cases of gland atrophy in non - HRT group. There was no significant difference between two groups （ P 〉 0.05 ）. Conclusion The breast structure and classification changes in HRT patients monitored by uhrasonograpy can guide the safety in HRT.