血清PSA及PSA密度与前列腺癌分级分期的关系

Correlations of Serum PSA and PSA Density with Grading and Staging of Prostatic Cancer

目的:提高前列腺癌(PCa)的诊断水平。方法:回顾了60例经穿刺活检确诊PCa患者的临床资料。结果:60例PCa患者中,血清T-PSA含量、F-PSA含量、F/T分别与PCa Gleason分级、临床分期均呈正相关,F/T与PCa Gleason分级、临床分期均无显著相关。结论:PCa患者的血清T-PSA、F-PSA和PSAD与Gleason分级和临床分期存在相关,提示可能通过检测血清T-PSA、F-PSA和PSAD预测PCa恶性程度及预后,有利于PCa的筛查及制定合理的治疗方案。

Objective： To improve diagnosis level of prostatic cancer. Methods： the clinical data of 60 cases of prostate cancer patients was retrospective analyzed who were diagnosed by needle biopsy was carried out. Results： in 60 cases of prostatic cancer patients,serum T-PSA content,F-PSA content and F/T were respectively positively correlated with and Gleason grading and clinical staging of prostatic cancer, while F/T had no significant correla- tion with Gleason grading and clinical staging of prostatic cancer. Conclusions：Serum T-PSA,F-PSA and PSAD of patients with prostatic cancer were respectively associated with clinical staging, indicating that it was possible to predict the grading malignancy and prognosis of prostatic cancer by detecting serum T-PSA,F-PSA and PSAD. It helped to screen prostatic cancer and prepare reasonable treatment plan.