膜联蛋白A1在前列腺癌中的表达及意义

Expression and significance of annexin A1 in prostatic cancer

目的:探讨膜联蛋白A1在前列腺癌组织、癌旁组织及正常前列腺组织中的表达及意义。方法:应用免疫组织化学SABC法检测膜联蛋白A1在61例前列腺癌组织、40例癌旁组织、40例正常前列腺组织中的表达,分析其在不同组织中表达情况。结果:在前列腺癌组织、癌旁组织、正常前列腺组织中膜联蛋白A1的阳性表达率分别为19.67%,22.50%和72.50%(P<0.01)。前列腺癌组织中膜联蛋白A1表达在年龄、肿瘤大小、组织分化程度、肿瘤浸润深度、有无淋巴结转移、TNM分期及远处转移等方面差异均无统计学意义(P>0.05)。结论:膜联蛋白A1表达异常可能成为前列腺癌早期诊断的重要指标。

Objective To study the expression and significance of annexin A1 in prostatic cancer tissue,normal tumor-adjacent tissue and normal prostate mucosa tissue.Methods The expression of annexin A1 was examined with immunohistochemical SABC method in 40 cases of normal prostate tissue,40 cases of normal tumor-adjacent tissue and 61 cases of prostatic cancer tissue.Results The expression rates of annexin A1 were 19.67%,22.5% and 72.5% in prostatic cancer tissue,normal tumor-adjacent tissue and normal prostate mucosa tissue（P〈0.01）.There were no significant differences in annexin A1 expressions in age,tumor size,tissue differentiation degree,tumor infiltration depth,lymph node metastasis,TNM staging or distant metastasis（P〈0.05）.Conclusion Abnormal annexin A1 expression may be an important index for the early diagnosis of prostate cancer.