摘要
胃癌是严重危害人民健康的疾病之一,其发病机制尚不明确.胃癌的发生常在癌变之前经历相当漫长的演变过程,即由正常胃黏膜转变成胃癌前病变,部分再发展成胃癌.目前公认,胃黏膜异型增生和肠上皮化生是胃癌前病变.鉴于胃癌的高度恶性,且其病因发病机制尚未完全阐明,实施针对病因的一级预防比较困难.本文就胃上皮内瘤变、异型增生和肠化生的定义和分类,幽门螺杆菌感染、萎缩性胃炎、肠化生与胃癌发生的相关性等问题进行综述,旨在提高对胃癌前病变的认识水平,以便于临床医师对胃癌前病变、特别是萎缩性胃炎进行密切的监测及予以及时有效的干预.
Gastric cancer is a common disease that greatly endangers people’s health.The mechanism of gastric carcinogenesis is still unknown.Gastric carcinogenesis is a long-term multistep process, during which a series of precancerous lesions develop sequentially.Intraepithelial dysplasia and intestinal metaplasia are two types of gastric precancerous lesions.Because of high malignancy and unclear etiology of gastric cancer,there are some difficulties in carrying out successful primary prevention.Here,we give an overview of the definitions and classification of gastric intraepithelial neoplasia and intestinal metaplasia, and elaborate the relationship among Helicobacter pylori infection,atrophic gastritis,intestinal metaplasia and gastric carcinoma.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第19期1981-1984,共4页
World Chinese Journal of Digestology
关键词
胃癌前病变
肠上皮化生
胃上皮内瘤变
幽门螺杆菌
干细胞
Gastric precancerous lesions
Intestinal metaplasia
Intraepithelial neoplasia
Helicobacter priori
Stem cells
