摘要
脂肪甘油三酯脂肪酶(ATGL)是近年来研究发现的启动脂肪动员的又一关键脂肪酶.ATGL能特异性地水解甘油三酯(TAG)的第一酯键,被认为是TAG水解过程的限速酶.ATGL在脂肪组织和非脂肪组织脂代谢过程中都发挥着重要作用,其活性和表达在细胞内受到转录水平、翻译后水平等调控.ATGL介导的脂解过程可能与肥胖、糖尿病、脂肪肝等代谢疾病存在关联.本文主要就ATGL的结构特征、生物学功能及其调控机制进行综述,并对今后的研究方向和应用进行了展望.
Recent studies showed that adipose triacylglyceride lipase（ATGL） functioned as an additional key enzyme for adipose lipid mobilization.ATGL specifically hydrolyzes the first ester bond of triglycerides and is a rate-limiting enzyme in triacylglycerol hydrolysis.The wide expression of ATGL suggested its important role in lipid metabolism in various tissue and cell types.The expression and activity of ATGL are regulated at both transcriptional and posttranslational levels.ATGL are also found to associate with obesity,diabetes,hepatic steatosis,and other related metabolic disorders.We focus on the discussion of structural characteristics,expression,biological functions,and regulatory mechanism of ATGL,and prospect on its potential application in the future.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2011年第8期721-727,共7页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家现代农业产业技术体系专项(No.CARS-43-6)资助~~
关键词
脂肪甘油三酯脂肪酶
甘油三酯
脂肪分解
代谢疾病
adipose triacylglyceride lipase（ATGL）
triacylglyceride
lipolysis
metabolic disorders
