电针对佐剂性关节炎大鼠炎症局部c-fos表达的影响

Effects of electroacupuncture on c-fos expression in inflamed location of adjuvant arthritic rats

目的：观察电针（ＥＡ） 对炎症痛模型佐剂性关节炎（ＡＡ） 大鼠炎症局部ｃ－ｆｏｓ 表达的影响，以探讨针刺对炎症痛的外周镇痛机制。方法：以福氏完全佐剂造成炎症痛模型ＡＡ，选取悬钟、昆仑穴ＥＡ治疗，采用免疫组织化学方法检测ｃ－ｆｏｓ 表达。结果：ＥＡ可以抑制ＡＡ 大鼠炎症局部ｃ－ｆｏｓ 的表达。结论：ｃ－ｆｏｓ 可能参与了ＥＡ对炎症痛的外周镇痛作用。

Aim :Toseekforperipheral mechanism ofelectroacupuncture(EA) analgesia,observed ef fectsof EAon c -fos expression in inflamed location in adjuvant arthritic(AA) rats ofinflammatory - pain model. Methods:Injected Freund’s complete adjuvantinto the right hind paw ofratsto produce AAmodel,stimulated Xuanzhong and Kunlun points with EA,adopted avidin biotin - peroxidase com plextechnique(ABC) to detect c -fos expression . Results:EA may modify c - fos expression in in flamedlocation in AArats. Conclusion:C- fos probably involve peripheral action of EAanalgesia on inflammatory- pain.