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LKB1-AMPK-mTOR信号传导通路在肿瘤中的研究进展 被引量：16

Advances of LKB1-AMPK-mTOR Signaling Pathway in Tumor
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摘要 肿瘤可以认为是一种基因疾病,其中癌基因的激活和抑癌基因的失活是肿瘤发生、发展过程中最为关键的环节之一。近年来,一个新的抑癌基因LKB1,又名STK11（serine threonine protein kinase11）,在肿瘤中的作用引起了越来越多的关注。
作者 张霞 孙琳琳 钟殿胜
机构地区 天津医科大学总医院呼吸科 天津医科大学总医院天津市肺癌研究所天津市肺癌转移与肿瘤微环境实验室
出处 《中国肺癌杂志》 CAS 2011年第8期685-688,共4页 Chinese Journal of Lung Cancer
基金 国家自然科学基金(No.30971307) 天津市应用基础及前沿技术研究基金(No.10JCYBJCI3700)资助~~
关键词 肿瘤发生 信号传导通路 protein 抑癌基因 基因疾病 LKB1
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献33

  • 1Hanahan D, Weinberg RA. The hallmarks of cancer. Cell, 2000, 100(1): 57-70.
  • 2Shaw RJ, Bardeesy N, Manning BD, et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell, 2004, 6 (1): 91-99.
  • 3Karuman P, Gozani O, Odze RD, et al. The Peutz-Jegher gene product LKB1 is a meditor of p53-dependent cell death. Molecular cell, 2001, 7(6): 1307-1319.
  • 4Baas AF, Boudeau J, Sapkota GP, et al. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. EMBO J, 2003, 22(12): 3062-3072.
  • 5Boudeau J, Baas AF, Deak M, et al. MO25alpha/beta interact with STRAD alpha/beta enhancing their ability to bind, activate and localize LKB 1 in the cytoplasm. EMBO J, 2003,22(19): 5102-5114.
  • 6Rowan A, Bataille V, MacKie R, et al. Somatic mutations in the Peutz-Jeghers (LKB 1/STKII) gene in sporadic malignant melanomas. J Invest Dermatol, 1999, 112(4): 509-511.
  • 7Hemminki A, Markie D, Tomlinson I, et al. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature, 1998, 391(6663): 184-187.
  • 8Giardiello FM, Brensinger JD, Tersmette AC, et al. Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology, 2000, 119(6): 1447-1453.
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  • 10Volikos E, Robinson J, Aittomaki K, et al. LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome. J Med Genet, 2006, 43(5): e18.

二级参考文献10

  • 1Matsumoto S,Iwakawa R,Takahash K,et al.Prevalence and specificity of LKB1 genetic alteration in lung cancer.Oncogene,2007,26:5911-5918.
  • 2Zhong D,Guo L,de Aguirre I,et al.LKB1 mutation in large cell carcinoma of the lung.Lung Cancer,2006,53:285-294.
  • 3Shaw RJ,Bardeesy N,Manning BD,et al.The LKB1 tumor suppressor negatively regulates mTOR signaling.Cancer Cell,2004,6:91-99.
  • 4Karuman P,Gozani O,Odze RD,et al.The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.Mol Cell,2001,7:1307-1319.
  • 5Zhong D,Liu X,Schafer-Hales K,et al.2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMP-activated protein kinase signaling activation or glycolysis inhibition.Mol Cancer Ther,2008,7:809-817.
  • 6Schneider PM,Praeuer HW,Stoeltzing O,et al.Multiple molecular marker testing (p53,C-Ki-ras,c-erbB-2) improves estimation of prognosis in potentially curative reacted non-small cell lung cancer.Br J Cancer,2000,83:473-479.
  • 7Ding L,Getz G,Wheeler DA,et al.Somatic mutations affect key pathways in lung adenocarcinoma.Nature,2008,455:1069-1075.
  • 8Hemminki A,Markie D,Tomlinson I,et al.A serine/threonine kinese gene defective in Peutz-Jeghers syndrome.Nature,1998,391:184-187.
  • 9Giardiello FM,Brensinger JD,Tersmette AC,et al.Very hish risk of cancer in familial Peutz-Jeghers syndrome.Gastroenterology,2000,119:1447-1453.
  • 10Sanchez-Cespedes M,Parrella P,Esteller M,et al.Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung.Cancer Res,2002,62:3659-3662.

共引文献1

同被引文献206

  • 1刘新垣.一个革命性的抗癌研究策略:癌症的靶向基因-病毒治疗[J].中国肿瘤生物治疗杂志,2015,22(2):159-165. 被引量：3
  • 2侯桂琴,范天黎,鲁照明,刘兰琦,许培荣,薛乐勋,王建人.EC9706和Eca109细胞中雷帕霉素靶蛋白信号通路激活状态观察[J].郑州大学学报（医学版）,2007,42(2):223-225. 被引量：11
  • 3臧远胜,夏天保,李强.抑癌基因LKB1对肺癌细胞血管内皮生长因子的表达调控[J].第二军医大学学报,2007,28(6):624-628. 被引量：4
  • 4Reuben JS, Monica K, Nabeel B, et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA, 101(10): 3329-3335.
  • 5Memmott RM, Gills JJ, Hollingshead M, et al. Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKBlmutant non small cell lung cancer cells. Cancer Res, 2008, 68(2): 580-588.
  • 6Shackelford DB, Shaw RJ. The LKB1-AMPK pathway: metabolism and growth controlin tumour suppression. Nat Rev Cancer, 2009, 9(8): 563-575.
  • 7Hadad SM, Fleming S, Thompson AM. Targeting AMPK: a new therapeutic opportunity in breast cancer. Crit Rev Oncol Hematol, 2008, 67( 1): 1-7.
  • 8Hadad SM, Appleyard V, Thompson AM. Therapeutic metformin/ AMPK activation promotes the angiogenic phenotype in the ER alpha negative MDAMB-435 breast cancer model. Breast Cancer Res Treat, 2009,114(2): 39l.
  • 9Ben SI, Laurent K, Loubat A, et al. The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene, 2008, 27(25): 3576-3586.
  • 10Buzzai M, Jones RG, Amaravadi RK, et al. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res, 2007, 67(14): 6745-6752.

引证文献16

二级引证文献56

中国肺癌杂志
2011年 第8期

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