艾滋病合并隐球菌脑膜炎患者实验室相关指标分析

Experimental analysis of acquired mnuaodeficency syndrome patients with cryptococcus neoformam meningitis

目的探讨艾滋病及其合并隐球菌脑膜炎患者实验室相关指标的变化及其临床意义。方法将我院收治的58例艾滋病患者，分为26例艾滋病患者（单纯感染组）、32例艾滋病合并隐球菌脑膜炎患者（合并感染组），分别对脑脊液和外周血常规及生化指标、T细胞亚群进行检测，分析两组间实验室检测指标的差异。结果合并感染组的脑脊液蛋白质为（601．284±545．24）mmol／L，高于单纯感染组（t=0．494，P〉0．05）；合并感染组的脑脊液氯化物和葡萄糖分别为（121．57±5．255）mmol／L和（1．944±0．678）mg／L，低于单纯感染组（t=0．129、1．984，P〉0．05）；合并感染组的外周血淋巴细胞、CD3细胞、CD4细胞、CD8细胞分别为（495．0±141．1）、（479．9±137．4）、（35．1-I-32．2）、（413．9±104．8）个／μL，均低于单纯感染组，两组比较差异有统计学意义（t=2．236、2．007、2．767、1．997，P〈0．05）。结论艾滋病合并隐球菌脑膜炎患者CIN细胞显著下降，临床上出现CD4细胞计数小于100个／止，CD3和CD8细胞明显下降或淋巴细胞绝对值明显低值，应重视病原学检验。．

Objective To study the clinic laboratory characters of AIDS with cryptococcus neoformans meningitis coinfection patients. Methods 58 cases of AIDS patients in our hospital were selected. All the cases were divided into two groups, 26 AIDS patients were infection group, while those with meningitis were eoinfection group. T lymphocytes, liver function, blood routine test were detected by the immunological, biochemical methods. Remdts Compared with the infection group, cerebral protein in coinfection group was high [ （601.28 ± 545.24） mn^l/L, t = 0.494, P 〉 0.05 ], CL and GLU in coinfection group were low [ （ 121.571 ±5.255） mmol/L and （ 1.944 ±0.678） rag/L, t = 0.129,1.984, P 〉 0.05 ]. In coinfectiun group, the counts of lymphocyte, CD3, CIM, and CD8 were （495.0 ±141.1 ）, （479.9 ± 137.4）, （35.1 ± 32.2）, （413.9 ± 104.8） cells/v.L separately. They were all lower than those in control group （t =2.236, 2.007,2.767,1.997, P 〈0.05）. C.smcl^ons The counts of CIM in AIDS patients with cryptococcus