人乳头瘤病毒治疗性疫苗综合疗法的研究现状与临床潜力

Research status and clinical potential of comprehemive therapy of the therapeutic vaccine for inmmn papillo.mavirus

近年来，人乳头瘤病毒（HPV）治疗性疫苗的研究一直处于非常热门的地位，不少研究已经进入临床试验。HPV是宫颈癌的主要诱因，除了肿瘤细胞逃逸免疫机制外，HPV本身也有其特殊的逃逸机制，因此单一有效的治疗性疫苗研发有其一定的难度。从研究趋势上看，HPV治疗性疫苗联合其他治疗方式的综合性治疗或许成为有效的最新的研究热点而被认为具有更高的临床应用潜力。此文就目前的联合HPV治疗性疫苗的综合治疗方法研究进展进行综述，同时展望了未来值得探索的方向。

In recent years, research on therapeutic vaccine for human papillomavirus （HI：＇V）and its clinical trials have been one of hot areas. HPV is the major cause of cervical cancer, in addition to regular immune escape mechanisms of HPV induced tumor cells, HPV also has a special escape mechanisms, this brings more di^culties to the development of therapeutic vaccine. Therefore a comprehensive treatment may be more effective for HPV-induced cervical cancer, and this is considered as the focus of latest research with a higher potential for clinical application. The recent progress on comprehensive therapy studies of the HPV therapeutic vaccine and explores directions worthy of future investigation are summarized in this review.