人乳头瘤病毒感染与宿主免疫应答

Hunm papmmvlrus infection and host immune response

人乳头瘤病毒（HPV）感染能引起人皮肤、黏膜良性增生性病变乃至宫颈癌等恶性肿瘤。ⅢⅣ不仅可以刺激宿主固有免疫和适应性免疫并产生一定的免疫应答，还可以通过多种免疫逃逸机制逃避宿主免疫应答而致持续感染。HPV与宿主免疫系统之间的相互作用决定了HPV感染后的临床表现和疾病转归。此文对HPV感染后宿主的免疫应答及可能的免疫逃逸机制进行了综述。

Human papillomavims （I-IPV） infection causes cutaneous and mucous benign proliferative lesions as well as malignancies such as cervical cancer. HPV induces certain low-level host innate and adaptive immune responses. In addition, HFV also employs several immune-evasion mechanisms to escape host immunity, thus facilitating persistent infection. The clinical manifestations and the outcome of HPV infection are determined by interaction of HPV with the host immune system. In this article, the host immune response to HPV infection and the possible mechnisms by which HPV can avoid the immune surveillance are reviewed.