摘要
IL-18是近年发现的一种炎性细胞因子，在结构上属于IL-1家族，但其生物学功能与11-12相似，主要发挥调节免疫的作用，诱导免疫细胞产生IFN7和介导细胞毒作用，在慢性HBV感染的发病机制中起重要作用。此文就IL-18的基本特性、免疫调节功能及在慢性HBV感染中的作用进行综述。
Interleukin- 18 is one of the inflammatory cells factor. The structure of IL- 18 is similar to IL- 1 family, but its biological function is similar to ID12, which mainly plays the role of immune regulation, inducing immune cells to produce intefferon-7 and mediating cytotoxic effects. It plays an important role in the pathogenesis of chronic HBV infec- tion. The basic character and immune re^un of IL-18 and its role in chronic HBV infection are reviewed in the article.
出处
《国际流行病学传染病学杂志》
CAS
2011年第4期287-290,共4页
International Journal of Epidemiology and Infectious Disease
