帕罗西汀和西酞普兰治疗抑郁症自杀未遂患者的疗效比较

Comparative study of Parocetine and Citalopram on treatment of depressive patients with attempted suicide

目的:比较帕罗西汀(赛乐特)和西酞普兰(喜普妙)治疗抑郁症自杀未遂患者的疗效和安全性。方法:用随机对照方法对75例抑郁症自杀未遂患者进行帕罗西汀(试验组)和西酞普兰(对照组)治疗8周,采用汉密尔顿抑郁量表(HAMD)评定疗效,用副反应量表(TESS)评定不良反应。结果:试验组在治疗后4周的HAMD减分值及减分率低于对照组,差异均有统计学意义(P<0.05)。两组在治疗后4周的显效率差异有统计学意义(P<0.05)。两组副作用比较无统计学意义(P>0.05)。结论:在系统治疗抑郁症自杀未遂患者时,西酞普兰抗抑郁作用显效快于帕罗西汀,两药安全性相仿。

AIM： To compare the clinical effect and safty of Parocetine and Citalopram on treatment of depressive patients with attempted suicide. METHODS- Using randomized study, 75 cases depressive patients with attempted suicide were evaluated by Hamilton rating scale for depression （HAMD） and Treatment emergent symotoms（TESS）. RESULTS：The effective rate of Parocetine after 4 weeks treatment was lower than that of Citalopram （P 〈 0.05）. There was significance difference. The significant efficiency had significance difference in two groups after 4 weeks treatment （P〈0.05）. The side effects of Parocetine and Citalopram had no differences （P 〉0.05）. CONCLUSION. Citalopram is rapidly responsive antidepressant for depressive patients with attempted suicide, and salty of Parocetine and Citalopram are similar.