炎症性肠病患者自身抗体检测及其临床意义

Detection of autoantibodies in inflammatory bowl disease

目的；检测炎症性肠病患者血清听 性粒细胞胞浆抗体，抗肠杯状细胞抗体，抗胰外分泌腺抗体三种自身抗体，并探讨三种自身抗体与ＩＢＤ中溃疡性结肠炎和克隆病的关系及临床诊断应用价值。方法：应用间接免疫荧光法。结果：ＡＮＣＮ在ＩＢＤ患者中，常见于ＵＣ，同ＣＤ比较有显著性差异；抗肠杯状细胞状抗体，抗胰外分泌腺抗体多见于ＣＤ。结论：抗中性粒细胞胞浆抗体，抗肠杯状细胞抗体，抗胰外分泌腺抗体三种自身抗体检测。

Objective:To investigate the relationship between autoimmune antibodies and inflammatory bowel disease (IBD),we detected three autoimmune antibodies including anti-neutrophil cytoplasmic antibody (ANCA),anti-intestinal goblet cells antibody and anti-pancreas acini cells antibody in sera from patients with IBD including ulcerative colitis (UC) and (crohn's disease (CD).The diagnostic value in clinical practice is also discussed.Methods:Indiret Immunofluorescence (ⅡF).Result:ANCA were more often detected in sera from patients with UC,and compared with CD there is signiflant difference {P< 0.001). Anti-intestinal goblet cells antibodies were detected with a higher frequency,in patients with UC than in patients with CD while anti-pancreas acini cells antibodies were detected with higher frequency in patients with CD than in patients with UC.Conclusion:Detection of autoantibodies including ANCA,intestinal goblet cells antibodies and anti-pancreas acini cell antibody may be of diagnostic value in patients with IBD and is helpful in distingwishing UC from CD.