上皮性卵巢癌中黏着斑激酶的表达及其意义

Expression and significance of FAK in epithelial ovarian cancer

目的:探讨上皮性卵巢癌中黏着斑激酶(focal adhesion kinase,FAK)蛋白的表达及其临床意义。方法:采用免疫组化染色、光镜观察结果确定FAK在良、恶性上皮性卵巢肿瘤组织中的蛋白表达,应用SPSS 13.0软件结合临床病理资料进行综合分析。结果:良、恶性上皮性卵巢肿瘤组织中FAK皆有表达,FAK在良性卵巢肿瘤组织中的表达多是弱阳性,表达率低;在卵巢癌组织中的表达多为阳性和强阳性,表达率高(72.0%,36/50),差异有统计学意义(P<0.01)。FAK表达与组织学分级、临床分期、淋巴结转移及不良预后明显相关(P<0.05),而与年龄、组织学类型无关(P>0.05)。结论:FAK在卵巢癌组织中的表达明显高于良性卵巢肿瘤组织,FAK可能参与了卵巢癌的发生、侵润和转移,在一定程度上可作为判断卵巢癌恶性程度及评估预后的一项重要指标。

Objective：To explore the expression of focal adhesion kinase（FAK） in epithelial ovarian cancer and its clinical significance.Methods：Immunohistochemical staining and microscopy were used to detect the expression levels of FAK in benign epithelial ovarian tumor and malignant epithelial ovarian cancer,then a comprehensive analysis was conducted on SPSS 13.0 software combined with clinicopathological data.Results：FAK both expressed in benign epithelial ovarian tumor and malignant epithelial ovarian cancer,the expression of FAK in benign epithelial ovarian tumor was weak positive,the expression rate was low;the expression of FAK in ovarian cancer was positive and strong positive,the expression rate was high（72.0%,36/50）,there was significant difference（P0.01）.The expression of FAK was related to histological grades,clinical stages,lymph node metastasis and prognosis obviously（P0.05）,but there was no correlation between the expression of FAK and age,histological types（P0.05）.Conclusion：The expression level of FAK in ovarian cancer is significantly higher than that in benign epithelial ovarian tumor,FAK may participate in the occurrence,invasion and metastasis of ovarian cancer,which can be used as an index to judge the malignant degree of ovarian cancer and evaluate prognosis to some extent.