依达拉奉治疗急性脑梗死96例疗效观察

Observation on the effect of edaravone in treatment of patients with acute cerebral infarction

目的 观察依达拉奉治疗急性脑梗死的疗效及其对血液流变学的影响.方法 96例脑梗死患者,随机分为观察组和对照组各48例.对照组采用常规溶栓治疗,溶栓后给予丹参静脉滴注;观察组在溶栓治疗后给予依达拉奉静脉滴注.观察两组疗效、神经功能缺损程度评分以及检测全血还原黏度、红细胞压积、红细胞沉降率、纤维蛋白原等血液流变学指标.结果 两组均取得了较好的疗效（总有效率分别为91.7%和72.9%）,神经功能缺损程度评分以及全血还原黏度、红细胞压积、纤维蛋白原等血液流变学指标均较治疗前显著好转.但观察组改善更为显著,两组差异均有统计学意义（均P＜0.05）.结论 依达拉奉可通过改善患者血液流变学状态而对脑梗死患者起到更好的治疗作用.

Objective To observe the effect of edaravone on haemorheology in the patients with cerebral infarction. Methods 96 patients with cerebral infarction were collected and randomly divided into observation group and control group. 48 patients were divided into each group. Conventional thrombolysis therapy was used in control group,and salvia miltiorrhiza intervenous drop infusion after thrombolysis. Edaravone intervenous drop infusion after thrombolysis was used in observation group. The curative effect,neurologic impairment score,and the haemorheology index（the whole reduced viscosity,hematocrit, ESR and fibrinogen） were detected in all patients. Results All the patients got a good curative effect, the improved neurologic impairment score and the haemorheology index after different treatment. The curative effect,the neurologic impairment score and the haemorheology index were better in observation group after treatment than that in control group （all P〈0. 05）. Conclusion Edaravone could play＇a better therapeutical effect in patients with cerebral infarction by cleaning the free radical and improving the state of haemorheology.