老年肺癌组织学类型、分化及P53蛋白表达

HISTOLOGICAL TYPES,DIFFERENTIATION AND EXPRESSION OF P53 PROTEIN OF LUNG CANCER IN AGED PATIENTS

目的:研究老年肺癌组织学特点及其P53蛋白的表达。方法:肺癌组织学类型按WHO标准进行分类,P53蛋白的表达采用免疫组化技术。结果:老年组肺癌的组织学类型与非老年组不同,差异有显著性(P<0.05);P53蛋白总阳性率为42.86%,两组间差异没有显著性(P>0.05)。结论:老年肺癌的组织学类型有其自己的特点,P53基因在肺癌的发生发展中具有重要意义。

Objective:To study the histological features and expression of P53 protein of lung cancer in aged patients.Methods:The histological types were determined according to the standard of WHO and the immunohistochemical staining was used to detect the expression of P53 protein.Results:There were significant differences in the histological types between the aged and nonaged patients.The total positive rate of P53 protein expression was 42.86% and there was no statistical differences between the two groups.Conclusion:The histological types of lung cancer in aged patients have their own features and P53 gene plays a significant role in the progression of lung cancer