Kallmann综合征的诊断与治疗（附11例报告）

Diagnosis and treatment of Kallmann syndrome （Report of 11cases）

目的探讨Kallmann综合征的诊断及治疗方法。方法回顾分析11例Kallmann综合征临床资料，全部病例伴嗅觉缺失或减退，同时给予促性腺激素和性激素联合替代治疗。结果随访12～23个月，平均15个月，所有患者阴茎长度、睾丸体积、性激素水平均较治疗前明显改善，第二性征均有不同程度的发育和改善。结论早期正确诊断是治疗Kallmann综合征的关键，及时给予激素替代治疗可以最大限度地促进睾丸发育，缓解患者的临床症状。

Objective To analyze the clinical diagnosis and treatment of Kallmann syndrome. Methods Clinical data of 11 patients with kallmann syndrome was retrospectively analyzed and the related literatures were reviewed. All patients had anosmia or hyposmia. All cases received the combined replacement therapy of gonadotropins and gonadal hormone. Results All 11 cases were treated during a follow-up period of 12-23 months （mean 15 months）. The penile length, testicular volume and sex hormone level after treatment were improved significantly than that of before treatment. The clinical features of hypogonadism were significantly improved in all treated patients. Conclusion Clinical symptoms of patients with Kallmann syndrome should be relieved significantly if they received early hormone replacement therapy.