柴胡疏肝散加减治疗功能性消化不良60例疗效分析

Analysis of Therapeutic Effect on 60 Cases of Functional Dyspepsia Treated by Modified Chaihu Shugan Powder

目的:观察柴胡疏肝散加减治疗功能性消化不良(FD)的效果、健康相关生活质量评分及尼群消化不良指数变化。方法:120例分为治疗组和对照组各60例,对照组用多潘立酮治疗,治疗组用柴胡疏肝散加减治疗,14天为一疗程,治疗2个疗程,分别于治疗前、治疗完成后、治疗后1个月填写健康相关生活质量评分表(the MOS 36-Item Short-Form Health Survcy,SF-36),尼平消化不良指数表(Nepean DyspepsiaIndex,NDI)。结果:两组治疗前后及治疗后两组间SF-36、NDI积分比较均有极显著性差异(P<0.01)。结论:柴胡疏肝散加减与多潘立酮治疗FD都有效,但柴胡疏肝散加减治疗对SF-36、NDI积分的改善近期和远期都优于多潘立酮。

Objective：To observe the effect,health related quality of life and the changes of Nepean dyspepsia index on 60 cases of functional dyspepsia（FD） treated by modified Chaihu Shugan Powder.Method：120 cases were divided into 2 groups evenly.The control group were treated by domperidone while the study group were treated by modified Chaihu Shugan Powder.One curative course was 14 days and both groups were treated for 2 courses.SF-36 scale and NDI scale were filled in at the time point of pre-treatment,post-treatment and one month after treatment.Result：There was very significant difference in SF-36 and NDI score in the two groups before and after treatment and there was also very significant difference in SF-36 and NDI score between the two groups after treatment（P0.01）.Conclusion：Both modified Chaihu Shugan Powder and domperidone have effect on FD,but modified Chaihu Shugan Powder is superior to domperidone in improving SF-36 and NDI score in short term and long term.