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人胎盘凝血活酶试剂的标定及其临床应用

Calibration of Human Placenta Thromboplastin and it′s Clinical Uses
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摘要 目的:标定自制人胎盘凝血活酶并应用于临床病人测定。方法:根据WHO 参比方法,用已知国际敏感指数(ISI) 的凝血活酶标定自制人胎盘凝血活酶;用进口试剂和自制品测定60例口服华法令抗凝治疗病人和40 例肝病患者的PT,求得PTR 和INR 并进行比较。结果:自制品ISI为1 .39 ,与进口品测定同一标本所得INR比较的回归方程为Y= 0 .9836X+ 0 .06249 ,两种试剂测定60 例抗凝治疗病人所得PT、PTR有明显差异而INR 无差异。用人胎盘凝血活酶测得40 例健康人INR为0 .80 ~1 .24 ,60 例机械性换瓣病人INR 值为1 .26 ~2 .92 。结论:自制人胎盘凝血活酶ISI值的标定是准确的,可以应用于临床。 Objective:To calibrate the self made human placenta thromboplast in and to use it to clinical detection Methods:Calibration of the self made thromboplastin was performed according to the method of ISI detection recommended by the WHO.The PT.PTR.and INR of 60 patients treated with oral anticoagulants and 40 patients with liver disorders were determined with the two kinds of thromboplastin reagents.Results:The ISI of the human placenta thromboplastin was 1.39.The PT and PTR determined with two kinds of thromboplastin reagents were different significantly,but the INR were very similar(Y=0.9836X+0.0629),with the human placenta thromboplastin used to determine,the INR of 60 patients treated with oral anticoagulants were 1.26~2.92,the INR of 40 healthy human plasmas were 0.80 ~1.24.Conclusion:The ISI of the self made human placenta thromboplastin is accurate,and this reagent can be used in the clinical fields.
出处 《四川省卫生管理干部学院学报》 1999年第4期241-243,共3页 Journal of Sichuan Continuing Education College of Medical Sciences
基金 四川省卫生管理干部学院资助
关键词 凝血活酶 人胎盘 国际敏感指数 国际标准化比率 Thromboplastin Human plactnta International sensitivity index International normalized radio
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