摘要
本文以Iso引起大鼠心肌缺血为模型,观察了NI对大鼠心肌缺血的影响。研究结果表明:NI显著降低轻度心肌缺血时心电图变化的电压;减少严重心肌缺血时心电图改变的鼠次;并减轻缺血心肌的病理变化。提示NI可能是通过阻滞钙离子的内流而对心肌起保护作用。
Naphthylmethyl Isoquinoline(NI) was modified from tetrandrine structure. This study wasundertaken to investigate the effects of NI on myocardial ischemia induced by Isoprenaline (Iso)in rats. The experimental results showed that NI (12mg/kg sc) remarkably lowered the voltageof electrocardiographic changes due to mild myocardial ischemia induced by Iso (3 mg/kg sc). NI(12mg/kg sc × 2) significantly decreased changes in electrocardiographic wave due to seriousmyocardial ischemia caused by Iso (6 mg/kg sc × 2), and it eased pathological changes of ischemicmyocardium. It is suggested that NI have a protective effect on myocardial ischemia induced byIso in rats through blocking of calcium influx into the cell.
