133例血压控制正常的高血压患者血压昼夜节律特点及调整用药后的变化

The Features of Circadian Rhythm of Blood Pressure and Feature Change after Shifting Administration on 133 Hypertensive Patients Normalized Diurnal Blood Pressure

目的:总结血压控制正常的原发性高血压患者的血压昼夜节律特点及调整用药后的变化。方法:对133例血压控制正常的原发性高血压患者进行动态血压监测(ABPM),随后对血压昼夜节律异常者进行用药调整,用药调整至白昼血压稳定在正常值之内后一周,再次行ABPM。结果:第一次ABPM结果:血压昼夜节律正常(杓型)28例,占21%,血压昼夜节律异常(非杓型、反杓型、超杓型)105例,占79%;第二次ABPM结果:105例再次受测者中,血压昼夜节律正常93例,占88%,血压昼夜节律异常12例,占11%。结论:依据ABPM结果,对高血压患者进行合理的降压药物选择及给药时间调整,不但可以有效降低高血压,还可以纠正血压昼夜节律异常,从而更趋全面地纠正血压异常。ABPM的应用对纠正血压昼夜节律异常有重要意义。

Objective：To sum the features of circadian rhythm of blood pressure and feature change after shifting administration on 133 hypertensive patients normalized diurnal blood pressure.Methods：Ambulatory blood pressure monitoring（ABPM）is operated firstly to the 133 hypertensive patients normalized diurnal blood pressure,then those with abnormal circadian rhythm of blood pressure is operated with ABPM second time after their blood pressure have been normalized for one week with new administration.Results：The first ABPM：28 patients（21%）show normal circadian rhythm of blood pressure（scoop type） and 105 patients（79%）show abnomal circadian rhythm of blood pressure（non-dipper type,reverse-dipper type and ultra-dipper type）.The second ABPM：among 105 patients operated with ABPM second time,93 patients（88%）show normal circadian rhythm of blood pressure and 12 patients（11%）show abnormal circadian rhythm of blood pressure.Conclusion：With the results of ABPM,not only hypertension but also abnormal circadian rhythm of blood pressure can be normalized by and overall restore the abnormality of blood pressure by approved administration.Application of ABPM signifficantly contribute to regulation of the circadian rhythm of blood pressure.