血必净治疗复苏后多器官功能障碍综合征的临床观察

Clinical observation of Xuebijing in the treatment of postresuscitation multiorgan dysfunction syndrome

目的观察血必净注射液治疗复苏后多器官功能障碍综合征的临床疗效。方法 80例复苏后多器官功能障碍综合征患者随机分为两组,对照组40例,采用常规治疗;血必净组40例,在常规治疗的基础上加用静脉注射血必净。观察两组治疗前及治疗后3天血清肿瘤坏死因子-a、白细胞介素-1、白细胞介素-6的水平。结果血必净治疗后第3d血清TNF-α、IL-1、IL-6均较治疗前明显下降(P<0.05),与对照组比较差异有显著性(P<0.05)。血必净组的生存率较对照组明显提高(P<0.01),血必净组住ICU的时间也比对照组明显缩短(P<0.01)。结论血必净治疗复苏后多器官功能障碍综合征疗效较好,可用于复苏后多器官功能障碍综合征的治疗。

【Objective】 To observe the clinical effect of Xuebijing injection in treating postresuscitation multiorgan dysfunction syndromes（PR-MODS）.【Methods】 Eighty patients with PR-MODS were randomly divided into two groups.Fourty cases in the control group were treated with normal medicine.Fourty cases in Xuebijing group were treated with normal therapy in combination with Xuebijing through intravenous injection.Two groups were compared on the levels of serum tumor necrosis-a（TNF-a）,interleukins-1（IL-1） and IL-6 after the treatment 3 day.【Results】 The levels of TNF-a,IL-1 and IL-6 of serum in Xuebijing group were significantly lower than those before the treatment and in the control group（P0.05）.The survival rate in Xuebijing group were significantly higher than those in the control group（P0.01）.Moreover,there was obvious difference between two groups in the total time in ICU（P0.01）.【Conclusion】 Xuebijing injection are effective on PR-MODS patients,and can be used in the treatment of PR-MODS.