丹参酮对急性冠状动脉综合征患者脂联素水平的影响

Effects of tanshinone on the level of adiponectin in patients with acute coronary syndrome

目的观察丹参酮治疗对急性冠状动脉综合征(ACS)患者脂联素水平的影响。方法将64例ACS患者入院后随机分为常规治疗组(n=32)及丹参酮治疗组(丹参酮IIA磺酸钠60mg/d,n=32)。分别于治疗前及治疗10d后应用酶联免疫法检测患者血清脂联素与高敏C反应蛋白(hs-CRP)水平,并观察血流变学及血脂水平的改变。结果治疗前后组内比较,两组患者血清TC、TG、LDL-C水平及全血粘度、血浆粘度、红细胞压积、血清hs-CRP均低于治疗前(P<0.05或P<0.01),血清脂联素浓度高于治疗前(P<0.01)。治疗10d后,与常规治疗组相比,丹参酮治疗组血TC、LDL-C明显减低(P<0.05),全血粘度、血浆粘度、红细胞压积及血清hs-CRP均低于常规治疗组(P<0.05或P<0.01),血清脂联素浓度高于常规治疗组(P<0.01)。结论丹参酮治疗能明显升高急性冠状动脉综合征脂联素水平,降低hs-CRP、TC、LDL-C水平并改善其血流变学状态。

【Objective】 To explore the effects of tanshinone on the level of adiponectin in patients with acute coronary syndrome（ACS）.【Methods】 Sixty-four patients with ACS were randomized into two groups（conventional treatment group,n=32 and tanshinone treatment group,n=32）after admission.Plasma centrations of adiponectin and high sensitive C-reactive protein（hs-CRP）were measured with ELISA method before and 10 days after therapy,meanwhile,the levels of lipids and hemorrheology indexes were assessed.【Results】 After treatment,the levels of TC 、TG、LDL-C、whole blood viscosity、plasma viscosity、hemotocrit、 hs-CRP were significantly reduced（P0.05或P 0.01） and levels of adiponectin were significantly increased（P 0.01） in both group.Compared to conventional treatment group,the levels of TC 、LDL-C、whole blood viscosity、plasma viscosity、hemotocrit、 hs-CRP were significantly reduced（P0.05或P 0.01） and levels of adiponectin were significantly increased（P 0.01） after 10 days,therapy in tanshinone treatment group.【Conclusion】 Tanshinone can significantly elevate the centration of adiponectin,decrease the levels of hs-CRP,TC,LDL-C and hemorrheology indexes in patients with ACS.